Quantcast

Neonatal jaundice ppt

| April 20, 2011 | 0 Comments

Neonatal jaundice ppt

PowerPoint lecture slide

Size: 369 KB

Download

 

Copy and visit the following link to download

http://dentistbd.blogspot.com/2012/07/download-link-dentistbd-click-on_9755.html


 

Jaundice is the most common condition that requires medical attention in newborns.
•In most infants, unconjugated hyperbilirubinemia reflects a normal transitional phenomenon.
•However, in some infants, serum bilirubin levels may excessively rise, cause death in newborns and lifelong neurologic sequelae in infants who survive (kernicterus).
•For these reasons, the presence of neonatal jaundice frequently results in diagnostic evaluation.

Pathophysiology of neonatal jaundice

Neonatal jaundice results the following phenomena:

  • vIncreased breakdown of fetal erythrocytes. This is the result of the shortened lifespan of fetal erythrocytes and the higher erythrocyte mass in neonates.
  • vHepatic excretory capacity is low both because of low concentrations of the binding protein ligandin in the hepatocytes and because of low activity of glucuronyl transferase, the enzyme responsible for binding bilirubin to glucuronic acid.
  • Certain factors present in the breast milk of some
    mothers may contribute to increased
    enterohepatic circulation of bilirubin (breast milk
  • increase bilirubin production through increased
    hemolysis.
  • Nonimmune hemolytic disorders (spherocytosis,
    G-6-PD deficiency) may also cause increased
Laboratory investigation
•A total serum bilirubin level is the only testing required in an infant with moderately jaundice.
•Blood type and Rh determination in mother and infant
•Direct Coombs testing in the infant
•Hemoglobin and hematocrit values.
•Peripheral blood film for erythrocyte morphology
•Reticulocyte count
•Tests for viral and/or parasitic infection: These may be indicated in infants with hepatosplenomegaly or other evidence of hepatocellular disease

 

© DENTIST BD BLOG . All rights reserved.
WARNING: Any unauthorised use or reproduction of  gr.dentistbd.com content for commercial or any purposes is strictly prohibited and constitutes copyright infringement liable to legal action.

Tags: , , , , , , , , , ,

Category: Lectures, Medicine

WARNING: Any unauthorised use or reproduction of  gr.dentistbd.com content for commercial or any purposes is strictly prohibited and constitutes copyright infringement liable to legal action.